1. Pharmacogenomics (also known as pharmacogenetics) explores how a person's genes metabolize medications.
2. Pharmacogenomics can help predict these side effects by identifying individuals with genes that increase their risk for SAMS.
3. – The CPIC guidance provides dosing recommendations for statins based on individual test results.
4. Beta-blockers are another common medication used in cardiology.
5. A forthcoming CPIC guideline will address beta-blockers and CYP2D6, and may recommend avoiding metoprolol in poor metabolizers.
6. Two common genetic variants in ADRB1 may decrease beta-blocker response
7. – Studies have shown that the PRP score can identify patients who are more likely to benefit from beta-blocker therapy.
8. Clopidogrel is an antiplatelet medication that can be metabolized differently by people with variations in the CYP2C19 gene
9. Pharmacogenomics is a rapidly evolving field with the potential to improve the effectiveness and safety of cardiovascular medications.